期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 8, 期 -, 页码 D855-D869出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1097
关键词
BMP; embryogenesis; patterning; gastrulation; receptor; kinase; skeletalgenesis; review
Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.
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