期刊
BIOLOGY OF THE CELL
卷 95, 期 3-4, 页码 211-219出版社
WILEY
DOI: 10.1016/S0248-4900(03)00038-8
关键词
translation; mRNA stability; Xenopus; deadenylation; RNA-binding protein
类别
Post-transcriptional regulations of gene expression (control of mRNA stability and translation) play a central role in achieving cellular functions. In a large number of cases, post-transcriptional regulations are dependent on mRNA poly(A) tails, as mRNAs with a long poly(A) tail are generally much more stable and actively translated than deadenylated mRNAs. In this review, we will discuss the activities that modify poly(A) tail lengths in Xenopus oocytes and embryos. We will particularly focus on one activity, the EDEN mechanism, that provokes specific poly(A) tail shortening rapidly after fertilization. EDEN-dependent deadenylation is mediated by the specific binding of a protein, EDEN-BP. The EDEN mechanism will be compared with several other mechanisms that provoke deadenylation in a large variety of species. The proposal that the EDEN mechanism is probably a mechanism of widespread importance in the inetazoan world will be discussed. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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