期刊
CELL CALCIUM
卷 33, 期 5-6, 页码 337-344出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0143-4160(03)00047-2
关键词
endoplasmic reticulum; Ca2+ entry; Ca2+ exit; exocrine gland cells
类别
Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the polarized nature of the secretory epithelial cells. In pancreatic acinar cells, for example, Ca2+ reloading of empty intracellular stores can occur solely via Ca2+ entry through the basal part of the plasma membrane. On the other hand, the principal site for intracellular Ca2+ release-with the highest concentration of inositol 1,4,5-trisphosphate (IP3) receptors-is in the apical secretory pole close to the apical plasma membrane. This apical part of the plasma membrane contains the highest density of Ca2+ pumps and is therefore the principal site for Ca2+ extrusion. On the basis of the known properties of Ca2+ entry and exit pathways in exocrine gland cells, the mechanisms controlling Ca2+ exit and entry are discussed in relation to recent direct information about Ca2+ transport into and out of the endoplasmic reticulum (ER) and the mitochondria in these cells. (C) 2003 Elsevier Science Ltd. All rights reserved.
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