期刊
BIOCHEMISTRY-MOSCOW
卷 68, 期 5, 页码 514-519出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1023947424341
关键词
antioxidants; flavonoids; oxidative stress; reactive oxygen species; asbestos; rutin; quercetin; epicatechins
Antioxidant properties and cytoprotective activity of flavonoids; (rutin, dihydroquercetin, quercetin, epigallocatechin gallate (EGCG), epicatechin gallate (ECG)) were studied. All these compounds inhibited both NADPH- and CCl4-dependent microsomal lipid peroxidation, and the catechins were the most effective antioxidants. The I-50 values calculated for these compounds by regression analysis were close to the I-50 value of the standard synthetic antioxidant ionol (2,6-di-tert-butyl-4-methylphenol). The antiradical activity of flavonoids to O-2(-) was studied in a model photochemical system. Rate constants of the second order reaction obtained by competitive kinetics suggested flavonoids to be more effective scavengers of oxygen anion-radicals than ascorbic acid. By competitive replacement all flavonoids studied were shown to be chelating agents capable of producing stable complexes with transition metal ions (Fe2+, Fe3+, Cu2+). The flavonoids protected macrophages from asbestos-induced damage, and the protective effect increased in the following series: rutin < dihydroquercetin < quercetin < ECG < EGCG. The cytoprotective effect of flavonoids was in strong positive correlation with their antiradical activity to O-2(-).
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