期刊
JOURNAL OF MASS SPECTROMETRY
卷 38, 期 5, 页码 523-525出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/jms.465
关键词
nanoelectrospray; polydimethylcyclosiloxane; cyclic silicone; background signals; air contaminants
Polydimethylcyclosiloxanes, an almost ubiquitous air contaminant, can interfere with nanoelectrospray analysis. The sensitivity of nanoelectrospray to these volatile air contaminants was demonstrated in this study. The intensity of the interfering ion signals caused by these compounds can be decreased by changing the position of the nanoESI needle and almost completely suppressed by applying a flow of pure nitrogen around the needle and the sample cone. The nitrogen flow causes a slight shift in charge distribution, but does not influence the sensitivity for peptide detection. Copyright (C) 2003 John Wiley Sons, Ltd.
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