期刊
INTERVIROLOGY
卷 46, 期 3, 页码 164-170出版社
KARGER
DOI: 10.1159/000071457
关键词
hepatitis B virus; hepatitis B e antigen; antibody to hepatitis B e antigen; chronic hepatitis; lamivudine; YMDD mutants
类别
Objective: The long-term effects of lamivudine and the influence of YMDD mutants on the histology of chronic hepatitis B are not known. Methods: 3-year lamivudine therapy was given to 16 patients with chronic hepatitis B. YMDD mutants did not develop in 9 patients (group A), while they appeared in the remaining 7 patients (group B). Results: Biochemical and virological responses were invariably achieved in the 9 patients without YMDD mutants, while virological breakthroughs with or without biochemical relapses occurred in all 7 patients with such mutants. All 16 patients accomplished histological improvement, with the total histology activity index (HAI) score decreasing from 11.3 +/- 3.0 to 4.1 +/- 1.7 (p < 0.001). The total HAI score decreased from 11.6 +/- 3.8 to 3.4 +/- 1.3 in the 9 patients in group A (p < 0.001). Although to a significantly lesser extent (p < 0.02), the total HAI score also decreased in the 7 patients in group B from 10.9 1.0 to 5.0 1.7 (p < 0.001). Conclusion: The results obtained indicate that 3-year lamivudine therapy can induce histological improvements, regardless of the appearance of YMDD mutants accompanied by virological breakthroughs and biochemical relapses. Copyright (C) 2003 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据