期刊
EXPERIMENTAL NEUROLOGY
卷 181, 期 1, 页码 47-56出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0014-4886(02)00055-9
关键词
growth factors; neurotrophic factors; spinal cord; spinal cord injury; regeneration; neurotrophins; axon growth
Nervous system growth factors promote axonal growth following acute spinal cord injury. In the present experiment, we examined whether delivery of neurotrophic factors after chronic spinal cord injury would also promote axonal growth and influence functional outcomes. Adult Fischer 344 rats underwent mid-thoracic spinal cord dorsal hemisection lesions. Three months later, primary fibroblasts genetically modified to express human neurotrophin-3 (NT-3) were placed in, and distal to, the lesion cavity. Upon sacrifice 3 months later (6 months following the initial lesion), NT-3-grafted animals exhibited significant growth of corticospinal axons up to 15 mm distal to the lesion site and showed a modest but significant 1.5-point improvement in locomotor scores (P<0.05) on the BBB scale, compared to control-grafted animals. Thus, growth factor gene delivery can elicit growth of corticospinal axons in chronic stages of injury and improves functional outcomes compared to non-growth-factor-treated animals. (C) 2003 Elsevier Science (USA). All rights reserved.
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