期刊
TRENDS IN GENETICS
卷 19, 期 5, 页码 238-242出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(03)00056-8
关键词
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We show that gene co-expression, which generally provides only a very weak signal for the prediction of functional interactions, can provide a reliable signal by exploiting evolutionary conservation. The encoded proteins of conserved co-expressed gene pairs are highly likely to be part of the same pathway not only after speciation (98%), but also after parallel gene duplication (97%). Conserved co-expression combined with homology data enables us to predict specific gene functions. The use of conservation between parallel duplicated gene pairs-to predict function is especially promising given that gene duplication is common in eukaryotes, and that data from only a single organism can be used.
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