Direct catalytic asymmetric aldol-type reaction of aldehydes with ethyl diazoacetate

[GRAPHICS] The direct aldol-type condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr((OBu)-Bu-t)(4) gave beta-hydroxy alpha-diazo carbonyl compounds with moderate enantioselectivities (53-87% ee).