期刊
FEBS LETTERS
卷 542, 期 1-3, 页码 147-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)00367-3
关键词
Parkinson's disease; alpha-synuclein; oxidative stress; nitration; fibrillation
资金
- NINDS NIH HHS [R01 NS39985] Funding Source: Medline
The aggregation of alpha-synuclein in dopaminergic neurons is a critical factor in the etiology of Parkinson's disease (PD). Oxidative and nitrative stress is also implicated in PD. We examined the effect of nitration on the propensity of alpha-synuclein to fibrillate in vitro. Fibril formation of a-synuclein was completely inhibited by nitration, due to the formation of stable soluble oligomers (apparently octamers). More importantly the presence of sub-stoichiometric concentrations of nitrated a-synuclein led to inhibition of fibrillation of non-modifled a-synuclein. These observations suggest that nitration of soluble a-synuclein may be a protective factor in PD, rather than a causative one. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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