期刊
BRAIN RESEARCH
卷 971, 期 2, 页码 239-244出版社
ELSEVIER
DOI: 10.1016/S0006-8993(03)02365-5
关键词
excitotoxicity; exercise; hippocampus; kainate; optical fractionator; stereology
资金
- NIA NIH HHS [AG13411, AG13880, AG15961] Funding Source: Medline
Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron number revealed that rats in the exercise condition exhibited significantly greater neuron loss in hippocampal region CA2/3, suggesting that high levels of physical activity may increase neuronal vulnerability to excitotoxicity. (C) 2003 Elsevier Science B.V. All rights reserved.
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