期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 278, 期 19, 页码 17060-17065出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M212212200
关键词
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An EID-1 ((E) under bar 1A-like (i) under bar nhibitor of (d) under bar ifferentiation-(1) under bar) inhibits differentiation by blocking the histone acetyltransferase activity of p300. Here we report a novel inhibitor of differentiation exhibiting homology to EID-1, termed EID-2 ((E) under bar ID-1- like (i) under bar nhibitor of (d) under bar ifferentiation-(2) under bar). EID-2 inhibited MyoD-dependent transcription and muscle differentiation. Unlike EID-1, EID-2 did not block p300 activity. Interestingly, EID-2 associated with class I histone deacetylases (HDACs). The N-terminal portion of EID-2 was required for the binding to HDACs. This region was also involved in the transcriptional repression and nuclear localization, suggesting the importance of the involvement of HDACs in the EID-2 function. These results indicate a new family of differentiation inhibitors, although there are several differences in the biochemical mechanisms between EID-2 and EID-1.
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