期刊
INTERNATIONAL JOURNAL OF CANCER
卷 104, 期 6, 页码 695-698出版社
WILEY
DOI: 10.1002/ijc.10975
关键词
BCL-2/J(H) translocation; biomarker; healthy; lymphocytes
类别
BCL-2/J(H) rearrangement has been proposed as a biomarker for evaluating the genotoxicity of occupational and environmental exposures. Available data on time-related modification of this rearrangement in peripheral blood lymphocytes in unexposed healthy individuals is scarce. We investigated the characteristics of BCL-2/J(H) rearrangements in 33 adults unexposed to genotoxins at 2 seasonal time points: winter and spring. BCL-2/J(H) rearrangement was detected in 79% of individuals (detection limit = 8.48 x 10(-8) Its frequency ranged from < 1 to 40 translocations per millio lymphocytes with a significant (p = 0.04) positive correlation with age. No significant modifications of BCL-2/J(H) rearrangement frequency or in the number of clones harboring this rearrangement were observed according the 2 time points. No obvious influence of season-related environmental factors on frequency or molecular features of BCL-2/J(H) rearrangements was found in this population suggesting that this would not be a confounding factor. (C) 2003 Wiley-Liss, Inc.
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