期刊
JOURNAL OF CELL BIOLOGY
卷 161, 期 3, 页码 653-660出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200302070
关键词
tight junction; central nervous system; endothelial cells; blood vessel; drug delivery
类别
Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (131313). Claudin-5 is a major cell adhesion molecule of tight junctions in brain endothelial cells. To examine its possible involvement in the BBB, claudin-5-deficient mice were generated. In the brains of these mice, the development and morphology of blood vessels were not altered, showing no bleeding or edema. However, tracer experiments and magnetic resonance imaging revealed that in these mice, the 131313 against small molecules (<800 D), but not larger molecules, was selectively affected. This unexpected finding (i.e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of 131313 but also opens a new way to deliver potential drugs across the 131313 into the central nervous system.
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