期刊
BRAIN RESEARCH BULLETIN
卷 60, 期 3, 页码 297-306出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0361-9230(03)00043-1
关键词
BBB; chemotherapeutics; analgesics; immunosuppressants; brain tumor; pain; Parkinson's disease; neuroprotection
One novel approach of transporting drugs into the central nervous system (CNS) involves the activation of receptors on the endothelial cells comprising the blood brain barrier (BBB). Recently the selective B, bradykinin receptor agonist, Cereport (also called RMP-7), has been shown to transiently increase permeability of the BBB. Although initially developed to increase the permeability of the vasculature feeding glioma, recent studies have demonstrated that Cereport also increases the delivery of pharmacological agents across the normal (i.e. nontumor) BBB. In this review paper, we discuss evidence of enhanced CNS delivery of carboplatin, loperamide, and cyclosporin-A, which are accompanied by enhanced chemotherapeutic, analgesic and neuroprotective effects, respectively. These observations suggest feasibility of Cereport as an adjunct therapy to pharmacological treatments that require drug availability in the CNS to exert therapeutic efficacy. Because many potential drugs for CNS disorders normally do not cross the BBB, Cereport-induced transient permeation of BBB stands as an efficacious strategy for enhancing pharmacotherapy. (C) 2003 Elsevier Science Inc. All rights reserved.
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