期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 413, 期 2, 页码 151-157出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0003-9861(03)00130-9
关键词
NFAT; NFAT5; TonEBP; hypertonicity; cell volume; cell size; intracellular environment; cell growth; transcription
资金
- NIGMS NIH HHS [GM59651] Funding Source: Medline
NFAT5/TonEBP, the most recently described member of the rel/NFkappaB/NFAT family of signal-dependent transcription factors, is activated by extracellular hypertonicity-a cellular stress of particular and perhaps unique physiologic relevance to cells of the renal medulla. Accumulating evidence suggests that NFAT5/TonEBP also functions in vivo under isotonic conditions as part of a ubiquitous regulatory mechanism that senses and adjusts available intracellular volume during cell growth to establish an intracellular environment appropriate for optimal cell proliferation. (C) 2003 Elsevier Science (USA). All rights reserved.
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