期刊
RESPIRATORY RESEARCH
卷 4, 期 4, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/rr199
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资金
- NCRR NIH HHS [P01 RR-15557, P20 RR015557] Funding Source: Medline
- NHLBI NIH HHS [P01 HL067004, HL 60793, HL 56638, P01 HL 67004] Funding Source: Medline
Measurement of the effects of drugs, mediators and infectious agents on various models of lung disease, as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However, the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness, data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless, considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease.
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