期刊
JOURNAL OF INFECTIOUS DISEASES
卷 187, 期 10, 页码 1534-1543出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/374786
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资金
- NCRR NIH HHS [5-M01-RR00083-37] Funding Source: Medline
- NIAID NIH HHS [P30 AI27763, R01 AI52745] Funding Source: Medline
- NIMH NIH HHS [P30 MH62246] Funding Source: Medline
Although T cell activation is associated with disease progression in untreated human immunodeficiency virus type 1 ( HIV-1) infection, its significance in antiretroviral- treated patients is unknown. Activated ( CD38(+) HLA-DR+) T cell counts were measured in 99 HIV-infected adults who had maintained a plasma HIV RNA level less than or equal to1000 copies/mL for a median of 21 months while receiving antiretroviral therapy. Patients with sustained viral suppression had lower levels of T cell activation than untreated patients but higher levels than HIV-uninfected control subjects. Persistent T cell activation was associated with decreased CD4(+) T cell gains during therapy. For every 5% increase in the proportion of activated CD8(+) T cells, 35 fewer CD4(+) T cells/ mm(3) were gained. Increased T cell activation was associated with shorter duration of viral suppression, hepatitis C virus coinfection, frequent low-level viremia, and lower nadir CD4(+) T cell counts. Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy.
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