期刊
CANCER LETTERS
卷 194, 期 2, 页码 199-208出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(02)00707-3
关键词
telomerase; telomere; p53; epithelial cell; immortalization; senescence; agonescence; conversion; tumor; cancer; oncogenesis; tumorigenesis; tumor suppressor
类别
资金
- NCI NIH HHS [CA-24844] Funding Source: Medline
Human epithelial cells encounter two senescence barriers that enforce a limited proliferative potential. A first barrier is mediated by the retinoblastoma protein, and can be overcome by multiple types of errors, many of which are observed in human cancers. A second, extremely stringent telomere-dependent barrier, is a consequence of repression of telomerase activity. Although relieved by ectopic hTERT expression, the nature of the errors required to overcome this latter barrier during in vivo carcinogenesis have not yet been defined. Attainment of immortality and telomerase reactivation are crucial to human carcinoma development; the derangements responsible for attainment of immortality may be rate-limiting and permissive for further progression to malignancy. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据