期刊
BEHAVIOURAL BRAIN RESEARCH
卷 141, 期 2, 页码 251-255出版社
ELSEVIER
DOI: 10.1016/S0166-4328(02)00374-1
关键词
neuropeptide Y; Y-2 receptors; anxiety; elevated plus maze; open field; mice
The behavioural phenotype of mice lacking neuropeptide Y (NPY) Y-2-type receptors was assessed in two well documented animal models of anxiety: namely, the elevated plus maze and the open field. NPY Y-2 -/- mice made more entries into, and spent significantly more time on, the open arms of the elevated plus maze when compared to their wild-type Y-2+/+ controls (P < 0.001). This effect was not due to non-specific changes in locomotor activity as the number of closed arm entries did not differ between groups. In addition, NPY Y-2-/- mice displayed increased preference for the central area of the open field when compared to Y-2+/+ animals (P < 0.01), whereas total entries did not differ between groups. This study suggests that NPY Y-2 receptors may play an inhibitory role and supports the hypothesis that Y-2 receptors are involved in the regulation of anxiety-like behaviours by NPY (C) 2002 Elsevier Science B.V. All rights reserved.
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