Convenient synthesis and efficient resolution of 3,3′-bis(benzyloxy)-1,1′-binaphthalene-2,2′-diol

The synthesis and resolution of 3,3'-bis(benzyloxy)-1,1'-binaphthalene-2,2'-diol 1 is described. A diastereomeric mixture of 7 (derived from (+/-)-1 and Boc-Ala-OH) was separated using crystallization and column chromatography. (C) 2003 Elsevier Science Ltd. All rights reserved.