Preparation and in vitro evaluation of GdDOTA-(BOM)4;: a novel angiographic MRI contrast agent

A novel Gd(III) complex, GdDOTA-(BOM)(4), has been prepared by a simple three-step procedure. The complex showed high T-1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T-1-relaxivity in plasma, 67.4 s(-1) mM(-1) (20 MHz, 37 degreesC), makes it a promising candidate for angiographic applications of MRI.