期刊
JOURNAL OF CELL BIOLOGY
卷 161, 期 4, 页码 673-677出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200302028
关键词
endocytosis; caveolae; glycolipid rafts; caveolin; dynamin
类别
Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. in this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.
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