期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 11, 页码 6670-6675出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1131852100
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资金
- NCI NIH HHS [CA38355, R37 CA038355] Funding Source: Medline
- NIAID NIH HHS [AI46710, AI21487, R01 AI046710] Funding Source: Medline
- NIA NIH HHS [P01 AG001743, AG01743] Funding Source: Medline
T cell stimulation usually requires direct contact with viable antigen-presenting cells (APCs). However, we show here that small exosome-like membrane vesicles shed from APCs can be recognized by naive CD8(+) T cells in the absence of viable APCs; T cell antigen receptor-dependent binding of vesicles by CD8(+) cells is MHC class I/pepticle-specific and requires that the vesicles coexpress intercellular adhesion molecule 1 (ICAM-1, CD54), although not B7 (B7-1). In the absence of B7, T cell binding of vesicles is nonimmunogenic. By contrast, vesicles expressing both ICAM-1 and B7 are strongly immunogenic and cause purified APC-depleted CD8(+) cells to mount peptide-specific proliferative responses and differentiate into effector cells.
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