期刊
BRAIN RESEARCH
卷 973, 期 2, 页码 214-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)02484-3
关键词
NOS; nitric oxide; sleep; rapid eye movement; electroencephologram; EEG
资金
- NICHD NIH HHS [HD 36520] Funding Source: Medline
- NINDS NIH HHS [NS 25378] Funding Source: Medline
Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in rapid eye movement sleep (REMS) regulation. To further investigate the role of NO in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes. REMS in nNOS KO mice was substantially lower than that of their control mice. In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation. (C) 2003 Elsevier Science B.V. All rights reserved.
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