期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 32, 期 3, 页码 822-U626出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.111.237271
关键词
acute coronary syndromes; ischemic heart disease; death; myocardial infarction; telomere length
资金
- Chief Physician Johan Boserup and Lise Boserup's Foundation
- Copenhagen County Foundation
- Danish Heart Foundation
Objective-We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. Methods and Results-We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n = 929), ischemic heart disease (n = 2038), and death (n = 4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies (P = 7 x 10(-74) to P = 3 x 10(-125)). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01-1.19) for myocardial infarction, 1.06 (1.00-1.11) for ischemic heart disease, and 1.09 (1.05-1.13) for early death per 1000-base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07-2.07) for myocardial infarction, 1.24 (1.01-1.53) for ischemic heart disease, and 1.25 (1.07-1.46) for early death. Conclusion-Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death. (Arterioscler Thromb Vasc Biol. 2012; 32:822-829.)
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