期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 32, 期 8, 页码 2029-U655出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.112.250589
关键词
telomeres; young; inflammation; C-reactive protein; cardiovascular risk factors
资金
- British Heart Foundation [CH/03/002/15570]
- Wellcome Trust [051187/Z/97/A]
- BUPA Foundation, UK
- European Commission within the Seventh Framework Programme) [278603]
- Rosetrees Trust [JS16/M147]
- Il Circolo
- UK Clinical Research Collaboration
- Department of Health's NIHR Biomedical Research Centre funding scheme
- Medical Research Council, UK [G0601625]
- MRC [G0900686, G0601625] Funding Source: UKRI
- British Heart Foundation [RG/08/008/25291] Funding Source: researchfish
- Medical Research Council [G0900686, G0601625] Funding Source: researchfish
Objective-Short leukocyte telomere length (LTL) is associated with cardiovascular (CV) disease in adulthood. However, the biological basis of this association remains unclear. We sought to define early determinants of the association between CV disease and LTL in an adolescent population. Methods and Results-One thousand eighty adolescents, aged 13 to 16 years and participating in the Ten Towns Heart Health Study, provided blood samples for DNA extraction and measurement of a range of CV risk factors. LTL was measured by real-time polymerase chain reaction. LTL was inversely associated with age (P=0.04), longer in females than in males (P=0.03), and longer in South Asians than in white Europeans (P=0.01). No associations were found between LTL and traditional CV risk factors. There was a significant and inverse association between LTL and inflammatory markers, including C-reactive protein (P<0.001) and fibrinogen (P=0.001). The associations between LTL and inflammatory markers were not affected by multiple adjustments for behavioral and metabolic factors. Conclusion-High levels of inflammation are associated with shorter LTL from early adolescence; traditional CV risk factors have little association with LTL in adolescence. Inflammation in early life may play a causal role in the adult association between short LTL and CV disease. (Arterioscler Thromb Vasc Biol. 2012;32:2029-2034.)
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