期刊
ANDROLOGIA
卷 35, 期 3, 页码 131-140出版社
WILEY
DOI: 10.1046/j.1439-0272.2003.00548.x
关键词
antioxidant enzymes; oxidative stress; testis; thyroid hormone
类别
The objective of the present experiment was to study the effect of thyroid hormone on the antioxidant defence system of rat testis. Hypothyroidism induced in rats by 6-n propyl 2-thiouracil (PTU) treatment resulted in a reduction in body weight, seminal vesicle and ventral prostate gland. A further decrease in the weight of seminal vesicle was recorded following administration of T-3 to hypothyroid rats. The oxidative stress parameters such as hydrogen peroxide and protein carbonyl content increased in the crude homogenate of testis of hypothyroid rats. T-3 administration to hypothyroid rats resulted in no further change in the hydrogen peroxide level but the protein carbonyl content further elevated in the crude homogenate of testis. No significant change was observed in the endogenous lipid peroxidation level of the crude homogenate of testis whereas the FeSO4 /ascorbic acid induced lipid peroxidation level decreased in hypothyroid rats and did not change further by T-3 administration. Although the reduced glutathione level in the crude homogenate of testis did not change following hypothyroidism, oxidized glutathione level increased. The reduced and oxidized glutathione level decreased and increased, respectively following T-3 administration to hypothyroid rats in comparison with PTU-treated rats. Activities of superoxide dismutase and catalase decreased in the post-mitochondrial fraction (PMF) of testis of hypothyroid rats. T-3 injection to PTU-treated rats resulted in an elevation in the level of catalase activity only. The activity of glutathione peroxidase in the PMF of testis elevated in the hypothyroid rats and reduced following T-3 treatment to hypothyroid rats. The results of the present study suggest that any alteration in the thyroid hormone level in the body affects the antioxidant defence system of testis of adult rats and, thereby, may affect the physiology of testis through oxidative stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据