期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 652-653出版社
PORTLAND PRESS
DOI: 10.1042/BST0310652
关键词
inflammatory cytokines; lipopolysaccharide responsiveness; systemic inflammatory response syndrome (SIRS); Toll-like receptor 4 (TLR4)
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299 --> Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P = 0.076), suggesting a role for TLIR4 signalling in the severity of SIRS.
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