期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 548-552出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0310548
关键词
dehydroquinone; dehydroquinone inhibitor; 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase); 6-fluoroshikimate; rational drug design; shikamate pathway
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
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