期刊
NEUROSCIENTIST
卷 9, 期 3, 页码 205-216出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858403009003013
关键词
synapse formation; GABARAP; GABAA receptors; receptor trafficking
The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABA(A) receptor-associated protein, GABARAP, was identified as a potential linker between GABA(A) receptors and microtubules. GABARAP belongs to an expanding family of proteins that are implicated in a variety of intracellular transport processes. GABARAP has been shown to interact with myriad binding partners, including the gamma2 subunit of the GABA(A) receptor, tubulin and microtubules, the N-ethyl maleimide sensitive factor, gephyrin, and the transferin receptor. The recent determination of the GABARAP crystal structure has revealed individual GABARAP domains, motifs, and surface regions involved in specific protein-protein interactions. Currently, a more general role is emerging for GABARAP, including shipping GABA(A) receptors to and from the cell surface, organizing them into postsynaptic clusters, and regulating the steady-state receptor density.
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