期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 31, 期 1, 页码 27-33出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.218123
关键词
apoptosis; atherosclerosis; endothelial function; endothelium; thrombin; thrombosis; vascular biology; microparticles
资金
- INSERM
- Universite de la Mediterranee [FRM-DCV20070409255]
- Assistance Publique Hopitaux de Marseille
- Paris-Descartes University
- Leducq Foundation (LINK Transatlantic Network)
- [ANR-06-Physio-038]
Endothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. They play a remarkable role in coagulation, inflammation, endothelial function, and angiogenesis and thus disturb the vascular homeostasis, contributing to the progression of vascular diseases. As a cause or a consequence, elevated levels of EMP were found in plasma from patients with vascular diseases, where they serve as a surrogate marker of endothelial function. More recent data challenged the presumed deleterious role of EMP because they could promote cell survival, exert antiinflammatory effects, counteract coagulation processes, or induce endothelial regeneration. This review focuses on the ambivalent role of EMP in vascular homeostasis. (Arterioscler Thromb Vasc Biol. 2011;31:27-33.)
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