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The present view of the mechanism of protein folding

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NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 4, 期 6, 页码 497-502

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NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1126

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We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.

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