期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 284, 期 6, 页码 G875-G879出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00549.2002
关键词
mitogen-activated protein kinase; hepatocyte; c-Jun; apoptosis; tumor necrosis factor
资金
- NIDDK NIH HHS [DK-61498, DK-44234, R01 DK044234, R01 DK061498] Funding Source: Medline
Activation of the JNK/activator protein-1 (AP-1)-signaling pathway is a common mediator of hepatocyte death from a variety of stimuli. Although the mechanism by which JNK or AP-1 promotes death is unknown, it results when activation of this signaling pathway is unusually prolonged. Although JNK/ AP-1 mediates TNF-induced cell death at or above the level of the mitochondria, the ability of JNK/ AP-1 to promote death from necrosis as well as apoptosis suggests that JNK/ AP-1 may induce death by several mechanisms. Recognition of JNK/ AP-1 signaling as a critical promoter of hepatocyte death raises the possibility that the therapeutic manipulation of this pathway may be effective in the treatment of human liver disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据