期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 31, 期 11, 页码 2760-2766出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.111.232991
关键词
stroke; thrombosis; von Willebrand factor; atrial fibrillation
资金
- Department of Internal Medicine [17896 CR 20]
- Mayo Clinic
- Foundation for Medical Education and Research
Objective-Left atrial blood stasis is associated with increased risk for left atrial appendage thrombus (LAAT) and stroke in atrial fibrillation (AF). Von Willebrand factor (VWF) is associated with thromboembolism in AF. VWF thrombogenic activity is proportional to multimer size, which is regulated by VWF-cleaving protease (ADAMTS13). Methods and Results-To assess the association between left atrial blood stasis and VWF-ADAMTS13 system, plasma VWF antigen (VWF:Ag), VWF activity (VWF: Act), and ADAMTS13 activity were measured in 414 consecutive patients with nonvalvular AF (age 63 +/- 13 years; 25% women) and in 100 patients (age 64 +/- 14 years; 39% women) with normal sinus rhythm. Spontaneous echocardiographic contrast (SEC), left atrial appendage emptying velocity, and LAAT were assessed by transesophageal echocardiography. Presence and intensity of SEC varied directly with VWF: Ag and VWF: Act but not with ADAMTS13 activity. AF patients with LAAT had higher VWF: Ag (200 +/- 61 versus 155 +/- 52, P=0.0006) and VWF: Act (179 +/- 57 versus 141 +/- 51 P=0.0026) compared with those without LAAT. VWF: Ag and VWF: Act were independent predictors of LAAT after adjustment for CHADS2 score (P=0.0179 and P=0.0497, respectively). Conclusion-The association between VWF and SEC may explain the thrombotic propensity in AF. Elevated VWF: Ag may help identify AF patients at risk for LAAT. (Arterioscler Thromb Vasc Biol. 2011;31:2760-2766.)
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