期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 30, 期 12, 页码 2357-2361出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.207480
关键词
leukocytes; platelets; signal transduction; thrombosis; inflammation
资金
- Fondazione Carichieti-Fondazione Negri Sud Onlus
- Ministero dell'Istruzione, dell'Universita e della Ricerca, Decreto Ministeriale (MIUR D.M.) [44/08]
- Comitato Esperti Politiche della Ricerca, Decreto Direttoriale (CEPR D,D) [484/Ric 2008]
- National Institutes of Health [HL080166]
Platelet-leukocyte interactions define a basic cell process that is characterized by the exchange of signals between platelets and different types of leukocytes and that bridges 2 fundamental pathophysiological events: atherothrombosis and inflammatory immune reactions. When this process takes place at the site of atherosclerotic plaque development or at the site of endothelial injury, platelet-dependent leukocyte recruitment and activation contributes to the inflammatory reaction of the vessel wall, which accounts for the exacerbation of atherosclerosis and for intimal hyperplasia and plaque instability. Moreover, platelet-leukocyte interactions may have a key role in modulating a wide array of responses of both the innate and adaptive immune systems, thus contributing to the pathogenesis of inflammatory diseases and tissue damage, as well as to host defense. (Arterioscler Thromb Vasc Biol. 2010;30:2357-2361.)
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