期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 30, 期 9, 页码 1695-1702出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.203034
关键词
vascular biology; gene silencing; lymphangiogenesis; notch signaling; zebrafish
资金
- Institute for the promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- EU [LSHG-CT-2004-503573]
- American Heart Association (AHA)
- Operational Network for Excellence in Lombardy's Biomedicine
- National Institutes of Health (NIH)
- Netherlands Organisation for Scientific Research (NWO)
- Royal Netherlands Academy of Arts and Sciences
- Federal Science Policy Office, Belgian State
Objective-To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. Methods and Results-In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. Conclusion-These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network. (Arterioscler Thromb Vasc Biol. 2010; 30: 1695-1702.)
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