期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 30, 期 4, 页码 648-652出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.108.181644
关键词
angiogenesis; gene therapy; ischemic biology; hypoxia; ischemia
资金
- National Institutes of Health [R01-HL55338, P20-GM78494, P01-HL65608, N01-HV28180]
- Johns Hopkins Institute for Cell Engineering
Blood vessels function as conduits for the delivery of O-2 and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes. (Arterioscler Thromb Vasc Biol. 2010; 30: 648-652.)
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