期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 30, 期 12, 页码 2372-2384出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.218131
关键词
gene expression; hemostasis; platelets; receptors; thrombosis
资金
- AstraZeneca
- Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership
- Daiichi Sankyo, Inc.
- Lilly USA, LLC
- Merck Research Laboratories
- Regado Biosciences, Inc.
- Medicines Company
- Sanofi-Aventis
- Schering-Plough
- Daiichi/Eli Lilly
- Schering Corporation
- BMS/Sanofi Partnership
- Johnson Johnson
- Merck and Co
- Regado Biosciences
Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo-and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy. (Arterioscler Thromb Vasc Biol. 2010;30:2372-2384.)
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