期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 47, 期 6, 页码 1979-1983出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.6.1979-1983.2003
关键词
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Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.
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