Antimycobacterial activity of 1-substituted indolizines

Indolizine derivatives were tested as anti mycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294) in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 mug/mL.