期刊
RESEARCH IN VETERINARY SCIENCE
卷 74, 期 3, 页码 241-245出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0034-5288(03)00003-1
关键词
pharmacokinetics; enrofloxacin; lactating sheep
The pharmacokinetics of enrofloxacin (ENR) was investigated after its intravenous (iv) and intramuscular (im) administration in six healthy lactating sheep. After iv ENR injection (as a bolus), the elimination half-life (t(1/2beta)), the volume of distribution (Vd(area)), and the area under the concentration vs. time curve (AUC) were 3.30 (0.36) h, 2.91 (0.17) l/kg and 4.19 (0.18) mug h/ml, respectively. The maximum milk concentrations of ENR (C-max), the area under the milk concentration vs. time curve (AUC(milk)) and the ratio AUC(milk)/AUC(serum) were 2.38 (0.14) mug/ml, 23.76 (2.21) mug h/ml and 5.62 (0.30), respectively. After im administration of ENR the t(1/2beta), C-max, time Of C-max (t(max)) and absolute bioavailability (F-abs) were 3.87 (0.10) h, 0.74 (0.07) mug/ml, 0.83 (0.12) h and 75.35%, respectively. The C-max, AUC(milk) and the ratio AUC(milk) AUC(serum) were 1.94 (0.13) mug/ml, 24.81 (2.25) mug h/ml and 8.15 (0.96), respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.
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