Pharmacokinetics of enrofloxacin in lactating sheep

The pharmacokinetics of enrofloxacin (ENR) was investigated after its intravenous (iv) and intramuscular (im) administration in six healthy lactating sheep. After iv ENR injection (as a bolus), the elimination half-life (t(1/2beta)), the volume of distribution (Vd(area)), and the area under the concentration vs. time curve (AUC) were 3.30 (0.36) h, 2.91 (0.17) l/kg and 4.19 (0.18) mug h/ml, respectively. The maximum milk concentrations of ENR (C-max), the area under the milk concentration vs. time curve (AUC(milk)) and the ratio AUC(milk)/AUC(serum) were 2.38 (0.14) mug/ml, 23.76 (2.21) mug h/ml and 5.62 (0.30), respectively. After im administration of ENR the t(1/2beta), C-max, time Of C-max (t(max)) and absolute bioavailability (F-abs) were 3.87 (0.10) h, 0.74 (0.07) mug/ml, 0.83 (0.12) h and 75.35%, respectively. The C-max, AUC(milk) and the ratio AUC(milk) AUC(serum) were 1.94 (0.13) mug/ml, 24.81 (2.25) mug h/ml and 8.15 (0.96), respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.