期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 28, 期 6, 页码 313-320出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(03)00112-9
关键词
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Integrins are one of the major families of cell-adhesion receptors. In the past year, the first structure of an integrin has been published, ligand-binding pockets have been defined, and mechanisms of receptor priming and activation elucidated. Like all major advances, however, these studies have raised more questions than they have answered about issues such as the mechanisms underlying ligand-binding specificity and long-range conformational regulation.
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