期刊
NUTRITIONAL NEUROSCIENCE
卷 6, 期 3, 页码 153-162出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1028415031000111282
关键词
APP/PS1 transgenic mice; signaling; cognitive behavior; blueberry supplementation
Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP+PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.
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