期刊
ARQUIVOS DE NEURO-PSIQUIATRIA
卷 70, 期 10, 页码 765-768出版社
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI: 10.1590/S0004-282X2012001000003
关键词
multiple sclerosis; brain atrophy; Expanded Disability Status Scale
The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. Methods: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. Results: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS >= 3 was -0.76 +/- 0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59 +/- 0.56, while in patients with an EDSS of 0 it was -0.38 +/- 0.42 (p=0.003). Discussion: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.
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