期刊
BIOCHEMISTRY AND CELL BIOLOGY
卷 81, 期 3, 页码 173-176出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/o03-041
关键词
linker histones; chromatin folding; charge neutralization; secondary structure
Linker histones stabilize folded chromatin, acting through their long C-terminal tails. The C-termini contain high percentages of evenly distributed lysine and arginine residues and have no secondary structure in solution. Hence, it has generally been believed that the C-termini function by shielding negative charges on the DNA backbone. However, recent evidence supports a mechanism of action of the linker historic C-terminus that involves formation of specific secondary structure(s) upon interaction with other components of the chromatin fiber.
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