Study of solubility of isoproturon by its complexation with β-cyclodextrin

The inclusion complexes of beta-cyclodextrin-isoproturon were prepared using techniques such as kneading, coevaporation, and co-precipitation. These complexes were characterised for physical properties and spectral studies such as UV, FTIR, and I (HNMR)-H-1 spectroscopy. To investigate the stoichiometry of the complexes Phase solubility method was adopted. Most of the complexes showed an increase in the dissolution rate of the herbicide. The best results were obtained when inclusion complexes were prepared by co-precipitation and co-evaporation method. Findings of this paper will allow the rational use of isoproturon with increase in its efficacy. (C) 2003 Published by Elsevier Science Ltd.