期刊
CURRENT OPINION IN IMMUNOLOGY
卷 15, 期 3, 页码 354-361出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00046-3
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B cells act as immune effectors, primarily through antigen-specific clonal expansion and plasma-cell differentiation. B1 (CD5(+)) B cells and marginal zone B cells dominate T-cell independent humoral responses under the molecular control of activated dendritic cells. Helper T cell-regulated B-cell responses draw on follicular B cells as precursors and rely on qualitatively different patterns of immune synapse formation to regulate B-cell fate. These activities culminate in the germinal center reaction, during which somatic hypermutation and antigen-driven selection produce and preserve high-affinity plasma cells with extended longevity and memory B cells as the sensitized precursors for antigen recall.
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