期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 139, 期 1-2, 页码 150-154出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(03)00154-1
关键词
leptin; cytokines; multiple sclerosis; interferon beta
The role of leptin was investigated in relapsing-remitting multiple sclerosis (MS). Control and MS patients showed comparable baseline serum leptin levels. During the first year of IFNbeta-1a treatment, leptin significantly decreased since 2 months after starting therapy in 11 patients who had no relapses. A significant decrease in IL12/IL10 ratio was observed in this group of patients only after I year of treatment. An increase of leptin was observed before the first clinical exacerbation in 13 relapsing patients. Leptin may play a pathogenic role in MS and can be a useful marker of disease activity and response to therapy. (C) 2003 Elsevier Science B.V. All rights reserved.
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