期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 446, 期 3, 页码 298-303出版社
SPRINGER-VERLAG
DOI: 10.1007/s00424-003-1028-9
关键词
Ca2+ entry channels; TRP channels; structure-function relationship; mechano-sensors; temperature sensors
类别
Transient receptor potential (TRP) channels provide an enormous variability of Ca2+ influx mechanisms triggered by a wide range of stimuli. In this review, we discuss the activation properties of the Ca2+- and Mg2+-permeable TRP channel of the vanilloid subfamily TRPV4. This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca2+ entry. Not much is known about the regulation of this channel. We will refer only to a mechanism of Ca2+-dependent inhibition of TRPV4. Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function.
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